Orally Fast-Disintegrating Resveratrol/Cyclodextrin Nanofibrous Films as a Potential Antioxidant Dietary Supplement

Encapsulation of dietary supplements into electrospun cyclodextrin (CD) inclusion complex (IC) nanofibers can pave the way for development novel delivery systems with orally fast-disintegrating properties. Here, resveratrol/CD-IC nanofibrous films were fabricated using electrospinning technique. Resveratrol is a well-known bioactive agent its antioxidant potential, and it commonly used in formulation supplements. hydroxypropylated (HP-) ?CD ?CD both encapsulation resveratrol free-standing films. SEM imaging confirmed uniform fibrous morphology The amorphization by complexation verified various techniques including FTIR, 1H NMR, XRD, DSC, TGA, computational modeling. Besides results all these techniques, phase solubility studies also revealed more favorable formation HP?CD compared to HP?CD. Nanofibrous obtained having ?100% loading efficiency without loss during process. amorphous distribution unique properties ensured fast disintegration saliva simulation. enhanced an improved property. polymeric resveratrol/pullulan film was formed as control sample. CD-IC showed faster disintegration/dissolution, higher/faster release profile, significantly better potential resveratrol/pullulan-based samples.